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Updated: Jul 19, 2026

Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 8, 2010
Serum activity of matrix metalloproteinases -2 and -9
G M Soboleva1, A V Shurshalina, G T Sukhikh
1Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow. soboleva_galina@hotmail.com
Abstract:
Matrix metalloproteinases belong to the key effectors of tissue remodeling in health and disease. Matrix metalloproteinases -2 and -9, the most prevalent representatives of this family, are expressed in the endometrium. Chronic endometritis concomitant with sterility and spontaneous abortions is associated with decreased content of matrix metalloproteinases in the endometrium. Chronic endometritis combined with sterility correlates with decreased serum activities of matrix metalloproteinases -2 and -9, which returns to normal after recovery. Measurements of serum activities of matrix metalloproteinases -2 and -9 are proposed for monitoring of the dynamics and treatment efficiency in chronic endometritis.
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