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Updated: Jul 19, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
Published on: January 10, 2017
Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer
Pavel Broz1, Sergey Driamov, Joerg Ziegler
1Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
Abstract:
To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
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