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Updated: Jul 19, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Processes of inference, schizotypal thinking, and obsessive-compulsive behaviour in a normal sample
Frederick Aardema1, Tamara M R Kleijer, Monique Trihey
1Centre de Recherche Fernand-Seguin.
Inferential confusion and schizotypal symptoms are linked to obsessive-compulsive behavior. These cognitive factors independently predict obsessive-compulsive behavior, suggesting new avenues for understanding and treatment.
Area of Science:
- Psychology
- Clinical Psychology
- Cognitive Science
Background:
- Previous studies indicate a relationship between inferential confusion and obsessive-compulsive symptoms.
- Obsessive-compulsive disorder (OCD) is a complex condition with various contributing factors.
Purpose of the Study:
- To investigate the relationship between inferential confusion, schizotypal symptoms, and obsessive-compulsive behavior in a general population.
- To determine if inferential confusion and schizotypal symptoms independently predict obsessive-compulsive behavior, controlling for neuroticism.
Main Methods:
- A cross-sectional study involving 108 participants from The Netherlands.
- Participants completed questionnaires assessing inferential confusion, schizotypal symptoms, and obsessive-compulsive behavior.
- Statistical analyses were performed to examine the relationships between the variables.
Main Results:
- Both inferential confusion and schizotypal symptoms were significantly related to obsessive-compulsive behavior.
- Inferential confusion and schizotypal symptoms shared common variance.
- Both factors independently predicted obsessive-compulsive behavior even after controlling for neuroticism.
Conclusions:
- Inferential confusion and schizotypal thinking play a significant role in obsessive-compulsive behavior.
- These findings suggest potential targets for therapeutic interventions in OCD.
- Further research is warranted to explore the mechanisms underlying these relationships.
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