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Dissection of the fusion machine of SARS-coronavirus

Megan W Howard1, Brian Tripet, Michael G Jobling

  • 1University of Colorado Health Sciences Center, Aurora 80045, USA.

Advances in Experimental Medicine and Biology
|October 14, 2006
PubMed
Abstract

No abstract available in PubMed .

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...