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Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line

Elke Scandella1, Klara K Eriksson, Tobias Hertzig

  • 1Kantonal Hospital St Gallen, Switzerland.

Advances in Experimental Medicine and Biology
|October 14, 2006
PubMed
Abstract

No abstract available in PubMed .

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Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...

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