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Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
Published on: December 9, 2025
A protocol for facial volume restoration with poly-L-lactic acid
Aimee L Leonard1, C William Hanke
1Laser and Skin Surgery Center of Indiana, Carmel, IN 46032, USA.
Journal of Drugs in Dermatology : JDD
|October 17, 2006
Summary
Poly-L-lactic acid injections restore volume by stimulating collagen. This guide details proper injection techniques for submalar and buccal areas to ensure optimal results and avoid complications.
Area of Science:
- Biomaterials science
- Dermatology
- Plastic surgery
Background:
- Poly-L-lactic acid (PLLA) is an injectable biodegradable synthetic polymer for subcutaneous volume restoration.
- Its mechanism involves a foreign body tissue response, promoting fibroblast production and neocollagenesis.
- Despite widespread use, there's limited published guidance on PLLA injection techniques.
Purpose of the Study:
- To present a detailed protocol for the correct injection technique of PLLA.
- To address the scarcity of information regarding PLLA administration.
- To guide practitioners in achieving successful volumetric correction and minimizing unintended outcomes.
Main Methods:
- A protocol for PLLA injection into the submalar and buccal regions is described.
- The technique focuses on appropriate placement for effective volume restoration.
- Emphasis is placed on critical aspects of injection to prevent adverse effects.
Main Results:
- The presented protocol facilitates successful PLLA administration.
- Correct technique is crucial for achieving desired volumetric correction.
- Proper PLLA placement minimizes the risk of long-lasting, unintended aesthetic results.
Conclusions:
- Mastering PLLA injection technique is essential for practitioners.
- This protocol provides a reliable method for submalar and buccal volume restoration.
- Adherence to proper technique ensures patient safety and optimal aesthetic outcomes with PLLA.

