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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Published on: February 7, 2019

Cycloaddition protocol for the assembly of the hexacyclic framework associated with the kopsifoline alkaloids

Xuechuan Hong1, Stefan France, José M Mejía-Oneto

  • 1Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

Organic Letters
|October 20, 2006
PubMed
Summary

Researchers developed a new synthetic route for kopsifoline alkaloids using a Rh(II)-catalyzed cascade. This approach efficiently constructs the complex hexacyclic framework, enabling access to these important natural products.

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