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Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
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[Severe imported malaria in adults]
R Petrognani1, E Peytel, C Ponchel
1Département d'anesthésie-réanimation urgences, hôpital d'instruction des armées Laveran, boulevard Laveran, BP 40, 13998 Marseille-Armées, France.
Medecine Et Maladies Infectieuses
|October 24, 2006
Summary
Severe malaria, often imported from endemic regions, can cause organ failure in non-immunized adults. Artemisinin derivatives offer rapid treatment for this Plasmodium falciparum infection.
Area of Science:
- Tropical medicine
- Infectious diseases
- Parasitology
Context:
- Severe malaria is defined by Plasmodium falciparum presence and organ dysfunction.
- Imported malaria cases in France primarily involve individuals returning from sub-Saharan Africa.
- Non-immunized adults are susceptible to severe malaria, presenting with multi-organ failure and sepsis.
Purpose:
- To outline the characteristics and treatment of severe imported malaria.
- To highlight the critical condition of severe malaria mimicking Gram-negative sepsis.
- To compare antimalarial treatment options.
Summary:
- Severe malaria involves asexual Plasmodium falciparum forms and organ dysfunction.
- Intravenous quinine is a standard treatment, while artemisinin derivatives (artemether, artesunate) provide rapid action.
- Management of severe malaria may require intensive care unit support, including mechanical ventilation and dialysis.
Impact:
- Informs clinicians about the presentation and management of severe imported malaria.
- Emphasizes the effectiveness of artemisinin derivatives in rapidly treating severe Plasmodium falciparum infections.
- Underscores the need for prompt intensive care for patients with multi-organ failure due to malaria.
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