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Updated: Jul 19, 2026

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
07:16

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Published on: March 1, 2022

The genetic regulation of pigment cell development

Debra L Silver1, Ling Hou, William J Pavan

  • 1Genetic Diseases Branch, NHGRI, NIH, Room 4A51, Bldg. 49, 49 Convent Drive, Bethesda, Maryland 20892, USA.

Advances in Experimental Medicine and Biology
|November 2, 2006
PubMed

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Background and Environment Affect Phenotype

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