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Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl.LiCl

Wenwei Lin1, Oliver Baron, Paul Knochel

  • 1Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.

Organic Letters
|November 17, 2006
PubMed
Summary

Direct magnesiation of functionalized aromatics is achieved using an OBoc directing group and TMPMgCl.LiCl base. This method enables the synthesis of highly substituted benzene derivatives with excellent yields.

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