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Updated: Jul 18, 2026
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Management of sepsis
Gina Howell1, Samuel A Tisherman
1University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
The Surgical Clinics of North America
|November 23, 2006
Summary
Severe sepsis is a major cause of surgical patient mortality. Recent therapies like early goal-directed therapy and activated drotrecogin alfa show improved outcomes, with future research promising further advancements.
Area of Science:
- Critical care medicine
- Surgical outcomes
- Infectious disease complications
Background:
- Severe sepsis is a significant cause of death in surgical patients.
- Traditional treatment focuses on source eradication and supportive care.
- Recent therapeutic advancements have emerged.
Purpose of the Study:
- To review current and emerging treatments for severe sepsis in surgical patients.
- To highlight the impact of recent therapeutic strategies on patient outcomes.
- To suggest future directions for improving severe sepsis management.
Main Methods:
- Review of recent clinical studies and therapeutic interventions.
- Analysis of treatment modalities including early goal-directed therapy, glucose control, drotrecogin alfa (activated), and steroid replacement.
- Discussion of the pathophysiology of severe sepsis.
Main Results:
- Early goal-directed therapy has demonstrated improved morbidity and mortality.
- Tighter glucose control contributes to better patient outcomes.
- Administration of drotrecogin alfa (activated) and steroid replacement show positive effects.
Conclusions:
- Current therapeutic advancements offer improved outcomes for severe sepsis.
- Further understanding of sepsis pathophysiology is crucial for future treatment development.
- Continued clinical research is essential to enhance severe sepsis management and survival rates.
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