Related Experiment Video
Updated: Jul 18, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
Mathematical modeling of intracellular signaling pathways
Edda Klipp1, Wolfram Liebermeister
1Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany. klipp@molgen.mpg.de
Abstract:
Dynamic modeling and simulation of signal transduction pathways is an important topic in systems biology and is obtaining growing attention from researchers with experimental or theoretical background. Here we review attempts to analyze and model specific signaling systems. We review the structure of recurrent building blocks of signaling pathways and their integration into more comprehensive models, which enables the understanding of complex cellular processes. The variety of mechanisms found and modeling techniques used are illustrated with models of different signaling pathways. Focusing on the close interplay between experimental investigation of pathways and the mathematical representations of cellular dynamics, we discuss challenges and perspectives that emerge in studies of signaling systems.
Related Concept Videos
Intracellular Signaling Cascades
Intracellular Signaling Cascades
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
MAPK Signaling Cascades
