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Updated: Jul 18, 2026

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
An empirical approach for thermal stability (Tm) prediction of PNA/DNA duplexes
Toshiyuki Takiya1, Yasuhiro Seto, Hideyo Yasuda
1Nippon Flour Mills Co., Ltd., 5-1-3 Midorigaoka, Atsugi 243-0041, Japan.
Nucleic Acids Symposium Series (2004)
|December 8, 2006
Abstract:
To predict the Tm value of PNA/DNA duplex, we performed to determine the melting temperature of several PNA oligomers. For Tm calculation model building, we searched the correlativity of measured Tm value and each base contents of PNA oligomer. Here, We propose a novel formula for thermal stability (Tm) prediction of PNA/DNA duplexes.
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