Synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker
Aya Shibata1, Yoshihito Ueno, Akira Matsuda
1Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
Nucleic Acids Symposium Series (2004)
|December 8, 2006
Abstract:
This paper describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stranded DNA or RNA in buffer solutions both with and without MgCl(2). Thus, these oligonucleotides would be useful as antisense oligonucleotides for targeting single-stranded RNA through triplex formation.
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