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Updated: Jul 18, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
[A three years follow-up study on microkeratome associated deep lamellar endothelial keratoplasty]
Yingfeng Shao1, Jiaqi Chen, Zheng Wang
1Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. syingfeng@msn.com
Purpose:
To investigate the therapeutic effects and side effects of microkeratome associated deep lamellar endothelial keratoplasty (MDLEK).
Method:
Six patients with bulbous keratopathy who underwent MDLEK were follow up for three years.
Results:
The best corrected visual acuity improved obviously in 5 cases within 3 months post operation and kept stable afterward during the follow up time. One of them even arrived 14/20. Meanwhile the Astigmatism averaged (2.04 +/- 1.19)D 3 months post operation and from then on decreased gradually. Pachymetry appeared almost normal and showed stabilization. Post-operative endothelial cells density decreased in a model similar to that in penetrating keratoplasty. Keratocytes were found to be normal by confocal microscope and there was no scar in the visual axial area 12 months post operation. The deep sutures caused no neovascularization and rejection.
Conclusion:
MDLEK is a safe and applied surgical therapy for bulbous keratopathy with shorter visual recovery time, lower astigmatism and approving optical property of post-operative corneal.
