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Updated: Jul 18, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Clinical observation on juvenile macular hole without trauma and hypermyopia
Tieying Zhao1, Qingshan Chen, Ming Li
1Shenzhen Ophthalmic Center, Medical College of Jinan University, Shenzhen Eye Hospital, Shenzhen 518001, China.
Purpose:
To investigate the clinical characteristics of juvenile macular hole without trauma and hypermyopia, and research the mechanism of macular hole.
Methods:
Sixty-seven patients less than 40 years of age were studied retrospectively from June 1998 to March 2003. Five cases (7 eyes) aged from 22 to 38 years were reported and the clinical characteristics that had macular hole without trauma or hypermyopia were summed up.
Results:
There was 1 male and 4 females with visual acuity from 0.08 to 0.8. The images of optical coherence tomography (OCT) showed full thickness macular hole in 5 patients (7 eyes), and the diameters were from 87 to 1043 microm. Among them, 2 cases were combined with retina pigmentosa; 1 case with binocular Coat's disease; 1 case had bilateral macular hole combined with Eagles' disease; 1 case was combined with 2-2.5PD old retinochoroidal lesion under middle-peripheral fundus, and 1.5 PD retinal pigment epithelium (RPE) defect on the optical disk.
Conclusion:
The juvenile macular hole without trauma and hypermyopia combined the different retina vascular damages and the RPE defects.
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