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Published on: February 17, 2023
[Detection rate of enterotoxigenic Staphylococcus aureus isolated from children with intestinal disbacteriosis]
Insights
Enterotoxigenic Staphylococcus aureus strains, particularly those producing staphylococcal enterotoxin A (SEA), are prevalent in children with intestinal dysbacteriosis. Detection rates decrease with age, highlighting the importance of identifying these strains in infants.
Area of Science:
- Microbiology
- Pediatrics
- Gastroenterology
Context:
- Intestinal dysbacteriosis is common in children.
- Staphylococcus aureus can produce enterotoxins.
- Assessing the pathogenic potential of S. aureus in children is crucial.
Purpose:
- To determine the prevalence of enterotoxigenic Staphylococcus aureus in children with intestinal dysbacteriosis.
- To compare the detection rates of strains producing staphylococcal enterotoxin A (SEA) and staphylococcal enterotoxin B (SEB).
- To investigate the relationship between the age of children and the detection rate of enterotoxigenic S. aureus.
Summary:
- Indirect hemagglutination assay and enzyme immunoassay were used to detect enterotoxigenic Staphylococcus aureus in the faeces of 62 children (3 months to 7 years) with intestinal dysbacteriosis.
- Strains producing SEA were most prevalent (40.3%), followed by SEB-producing strains (20.9%).
- Enterotoxin production varied, with SEA ranging from 125-2000 ng/ml and SEB from 125-250 ng/ml. Detection rates showed an inverse correlation with age, being highest in infants.
Impact:
- Findings underscore the significance of identifying enterotoxin-producing S. aureus in pediatric dysbacteriosis.
- This assessment aids in evaluating the risk posed by S. aureus to children's health.
- Results support targeted interventions for eliminating enterotoxigenic S. aureus in affected children.
Abstract:
Detection rate of enterotoxigenic Staphylococcus aureus isolated from faeces of 62 children aged from 3 months old to 7 years old with intestinal dysbacteriosis was studied by indirect hemagglutination assay and enzume immunoassay. It was shown that strains of S.aureus producing staphylococcal enterotoxin A (SEA) are prevailed (40.3%) in children with disturbances of intestinal microflora while staphylococcal enterotoxin B (SEB)-producing strains were detected in 20.9% of children. Amount of produced enterotoxin varied for SEA from 125 ng/ml to 2000 ng/ml and for SEB--from 125 ng/ml to 250 ng/ml. Inverse dependence of detection rate of enterotoxin-producing strains in faeces on age of children was established. The most number of enterotoxigenic strains of S.aureus was detected in infants. These data point to expediency of determination of enterotoxin-producing ability of S. aureus strains isolated from children with dysbacteriosis as measure of danger of this microorganism for children's health and indication for adequate actions for its elimination.
