Related Experiment Video
Updated: Jul 18, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
A new HLA-A*31 null allele, A*3114N
D M Smith1, W B Gardner, J E Baker
1Department of Pathology, Transplant Immunology Laboratory, Baylor University Medical Center, Dallas, TX 75246, USA. dsmith@baylorhealth.edu
Tissue Antigens
|December 21, 2006
Summary
A novel Human Leukocyte Antigen (HLA)-A*31 null allele was identified. This genetic variation arose from an insertion mutation in exon 4, specifically an additional cytosine within a sequence of seven Cs.
Area of Science:
- Immunogenetics
- Molecular biology
- Human leukocyte antigen (HLA) research
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Null alleles can impact immune system function and disease susceptibility.
- Previous characterization of HLA-A*31 alleles is extensive.
Purpose of the Study:
- To report the discovery and initial characterization of a new HLA-A*31 null allele.
- To describe the molecular basis of this novel allele.
Main Methods:
- Sequence analysis of HLA-A*31 gene.
- Identification of novel nucleotide variations.
Main Results:
- A new HLA-A*31 null allele has been identified.
- The mutation involves the addition of an extra cytosine (C) in exon 4.
- This insertion occurred within a run of seven consecutive Cs.
Conclusions:
- The identified mutation results in a non-functional HLA-A*31 allele.
- This discovery contributes to the understanding of HLA polymorphism.
- Further studies are warranted to assess the functional and clinical implications of this null allele.
Related Concept Videos
02:41Lethal Alleles
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
01:49Multiple Allele Traits
The Concept of Multiple Allelism