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Updated: Jul 18, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Effect of complex phytoadaptogen on MPTP-induced Parkinson's syndrome in mice
E V Bocharov1, V G Kucheryanu, G N Kryzhanovskii
1Laboratory of General Pathophysiology of Nervous System, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Abstract:
Oral administration of 10% solution of Phytomix-40 (multicomponent plant phytoadaptogen) to C57Bl/6 mice with MPTP-induced Parkinson's syndrome alleviated symptoms (oligokinesia and muscle rigidity), compensated for the deficiency of dopamine and its metabolites (DOPAC and homovanillic acid), and reduced the level of lipid peroxides in the striatum. In vitro Phytomix-40 in a concentration of 3.3 x 10(-2) g/liter exhibited a pronounced antioxidant effect (5-fold decreased MDA level in mouse brain homogenate in Fe(2+)-ascorbate-dependent LPO).
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