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Primary systemic amyloidosis presenting as extensive cutaneous ulceration
Mohammed Alhaddab1, Herbert Srolovitz, Nathan Rosen
1Department of Dermatology, McGill University Health Centre, Montreal, QC, Canada. malhaddab@yahoo.ca
Background:
We report a case of primary systemic amyloidosis in a 78-year-old Caucasian woman presented as a nonhealing ulcer on the right thigh for 3 months. Histopathology of the skin revealed widely thickened walls of middermal and subcutaneous vessels from deposition of amorphous eosinophilic material that stained positively with Congo red and crystal violet.
Objective:
This case represents a very unusual presentation of primary systemic amyloidosis, one in which the cutaneous manifestations provided the first signs of a devastatingly widespread multiorgan infiltration of amyloid protein.
Conclusion:
This presentation of the disease may signify an advanced stage with a grave prognosis as our patient passed away 3 months after development of the cutaneous ulceration.
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