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Updated: Jul 17, 2026
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A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Low-level laser effect on mandibular distraction osteogenesis
Michael Miloro1, Jason J Miller, Julie A Stoner
1Section of Oral and Maxillofacial Surgery, University of Nebraska Medical Center, Omaha, NE 68198-5180, USA. mmiloro@unmc.edu
Summary
Low-level laser (LLL) therapy accelerates bone regeneration during distraction osteogenesis. This innovative approach may shorten healing times and reduce patient morbidity by enabling earlier device removal.
Area of Science:
- Regenerative Medicine
- Orthopedic Surgery
- Biophotonics
Background:
- Distraction osteogenesis is a surgical technique used to repair bone defects.
- Prolonged consolidation phases can lead to patient morbidity.
Purpose of the Study:
- To investigate if low-level laser (LLL) application accelerates bone regeneration during distraction osteogenesis.
- To determine if LLL reduces the consolidation phase and associated patient morbidity.
Main Methods:
- Bilateral mandibular corticotomies were performed on rabbits with distraction devices.
- One side received LLL treatment (6.0 J x 6) immediately after device activation.
- Radiographic and histologic analyses, including Bone Healing Score (BHS), were used to assess bone regeneration.
Main Results:
- LLL-treated bone showed higher BHS radiographically at all time points.
- Histologic examination revealed more advanced new bone formation and ossification in the LLL group.
- Complete inferior border formation occurred sooner in the LLL-treated rabbits.
Conclusions:
- Low-level laser therapy significantly accelerates bone regeneration during the consolidation phase of distraction osteogenesis.
- Adjunctive LLL may shorten consolidation periods, allowing for earlier device removal and reduced patient morbidity.
