[The release of biologically active substances from blood leukocytes in allergic diseases]

Elevated spontaneous liberation of biologically active substances from the peripheral blood leukocytes was revealed in 42% of children suffering from various allergic conditions. This liberation was particularly marked during the disease exacerbation and in grave forms of allergies in the patients with elevated serum IgG levels and in those with bronchial hyperreactivity. Liberation of biologically active substances was more often recorded in schoolchildren than in preschool children. Membrane stabilizers (intal and zaditen) were more effective in the patients with elevated liberation of biologically active substances. The authors have analyzed the conditions of tests for spontaneous liberation of biologically active substances and some characteristics of these biologically active substances.