[Human papillomavirus-associated cutaneous lesions].

Area of Science:

• Dermatology
• Virology
• Oncology

Context:

• Human papillomaviruses (HPV) are common viruses affecting human epithelia.
• HPV infections manifest as benign skin lesions, particularly on hands and soles.
• The link between genital HPV and cervical cancer is established, but HPV's role in skin cancer requires further investigation.

Purpose:

• To review the clinical presentations of HPV-induced skin lesions.
• To discuss the challenges in treating HPV-related warts.
• To explore the potential role of HPV in skin carcinogenesis, alongside other co-factors.

Summary:

• HPV infections are widespread, causing various benign skin warts like common, filiform, and flat warts.
• Treatments for these warts are often invasive and challenging due to persistent HPV infection.
• While HPV is linked to cervical cancer, its specific contribution to skin cancers such as Bowen's disease and squamous cell carcinoma, possibly with UV radiation and immune suppression, needs more study.

Impact:

• Provides a comprehensive overview of HPV skin manifestations and treatment difficulties.
• Highlights the need for further research into HPV's role in skin cancer development.
• Informs clinicians and researchers about the complexities of HPV pathogenesis in epithelial cancers.