Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

17.0K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.9K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kaposi's Sarcoma: Evaluation of Clinical Features, Treatment Outcomes, and Prognosis in a Single-Center Retrospective Case Series.

Cancers·2024
Same author

Health Economic Consequences Associated With COVID-19-Related Delay in Melanoma Diagnosis in Europe.

JAMA network open·2024
Same author

Thirty-two-year trends of cancer incidence by sex and cancer site in the Veneto Region from 1987 to 2019.

Frontiers in public health·2024
Same author

Highly biocompatible material for enhanced abdominal wall repair: a retrospective study with EGIS<sup>®</sup> porcine dermal matrix.

Case reports in plastic surgery & hand surgery·2024
Same author

Gender Differences in Soft Tissue and Bone Sarcoma: A Narrative Review.

Cancers·2024
Same author

Desmoid Tumors in the Active Surveillance Era: Evaluation of Treatment Options and Pain Relief in a Single-Center Retrospective Analysis.

Journal of personalized medicine·2023
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.6K

Tumor immunology.

Simone Mocellin1, Mario Lise, Donato Nitti

  • 1Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, University of Padova, Via Giustiniani 2, Italy. mocellins@hotmail.com

Advances in Experimental Medicine and Biology
|February 3, 2007
PubMed
Summary
This summary is machine-generated.

High-throughput microarray analysis is accelerating discoveries in tumor immunology by revealing molecular mechanisms of immune-mediated tumor rejection. This technology offers new hypotheses for cancer immune response, despite interpretation challenges.

More Related Videos

Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

15.6K
Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
10:58

Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

Published on: January 2, 2011

10.5K

Related Experiment Videos

Last Updated: Feb 10, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

2.6K
Imaging the Human Immunological Synapse
09:37

Imaging the Human Immunological Synapse

Published on: December 26, 2019

15.6K
Facilitating the Analysis of Immunological Data with Visual Analytic Techniques
10:58

Facilitating the Analysis of Immunological Data with Visual Analytic Techniques

Published on: January 2, 2011

10.5K

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Current immunotherapies show varied success, highlighting gaps in understanding immune-mediated tumor rejection mechanisms.
  • The complex interplay within the immune system and tumor/host interactions necessitates advanced analytical tools.

Purpose of the Study:

  • To explore the application of high-throughput microarray analysis in tumor immunology.
  • To accelerate the discovery of molecular mechanisms underlying immune responses against cancer.
  • To generate novel hypotheses in cancer cell biology.

Main Methods:

  • Utilizing DNA microarray technology for genome-wide analysis of immune responses.
  • Profiling gene expression to understand molecular kinetics in tumor immunology.

Main Results:

  • Microarray implementation has yielded significant data in tumor immunology.
  • Intriguing new hypotheses regarding the molecular cascade of anti-cancer immune responses have emerged.
  • Demonstrated the potential of microarray technology in advancing oncology research.

Conclusions:

  • DNA microarray analysis is a powerful tool for advancing tumor immunology research.
  • Mastering microarray data interpretation is crucial for generating meaningful insights in cancer research.
  • Continued application of this technology promises to catalyze new discoveries in cancer immunology.