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Published on: June 5, 2019
Surface characterization and platelet compatibility evaluation of the binary mixed self-assembled monolayers
Meng-Yen Tsai1, Yu-Ting Sun, Jui-Che Lin
1Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.
Journal of Colloid and Interface Science
|February 3, 2007
Summary
Mixed self-assembled monolayers (SAMs) improve surface packing and platelet compatibility. Hydrophilic PO3H2+OH SAMs show superior hemocompatibility compared to PO3H2+CH3 SAMs, indicating surface wettability and charge density are key factors.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Nanotechnology
Background:
- Self-assembled monolayers (SAMs) are crucial for controlling surface properties.
- Steric hindrance can impact SAM packing density and functionality.
- Platelet compatibility is a critical factor for biomedical materials.
Purpose of the Study:
- To investigate the effect of steric hindrance on SAM packing quality.
- To evaluate the platelet compatibility of mixed SAMs with varying compositions.
- To understand the relationship between surface properties and hemocompatibility.
Main Methods:
- Formation of binary mixed SAMs using alkanethiols with different terminal groups (PO3H2, CH3, OH).
- Surface characterization using techniques like X-ray photoelectron spectroscopy (XPS).
- In vitro platelet adhesion assays to assess hemocompatibility.
Main Results:
- Hydrophilicity of mixed SAMs reached a plateau with increasing PO3H2 thiol concentration.
- Addition of CH3 and OH thiols improved SAM packing quality by reducing steric hindrance.
- PO3H2+OH SAMs exhibited better platelet compatibility than PO3H2+CH3 and pure PO3H2 SAMs.
- Low PO3H2+OH SAMs showed minimal platelet activation.
Conclusions:
- Mixed SAMs offer a strategy to optimize surface properties for enhanced hemocompatibility.
- Surface wettability and charge density collectively influence platelet compatibility.
- PO3H2+OH SAMs present a promising surface modification for biomedical applications.
