Wireless multichannel integrated potentiostat for distributed neurotransmitter sensing
Kartikeya Murari1, Christian Sauer, Milutin Stanacevic
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205. kartik@jhu.edu.
Summary
This study presents an integrated device for sensing neurotransmitters, featuring a wireless power harvesting and telemetry module. The device enables real-time, multi-channel dopamine concentration monitoring in vitro.
Area of Science:
- Neuroscience
- Electrical Engineering
- Biomedical Engineering
Background:
- Sensing neurotransmitters is crucial for understanding neural pathways and neurological disorders.
- Existing methods for neurotransmitter detection can be limited by power supply and data transmission.
Purpose of the Study:
- To develop an integrated device for wireless neurotransmitter sensing.
- To demonstrate real-time, multi-channel acquisition of dopamine concentration.
Main Methods:
- Fabrication of a 16-channel potentiostat with microampere to picoampere scales in CMOS technology.
- Integration of a wireless module for power harvesting (inductive coupling) and data telemetry.
- Experimental characterization of the device, including RF powering noise analysis.
- In vitro dopamine concentration measurement using carbon fiber sensors.
Main Results:
- The integrated device successfully performed real-time, multi-channel acquisition of dopamine concentration.
- Radio frequency (RF) powering introduced minimal noise (0.42% at 500pA, 0.18% at 4nA).
- The device demonstrated effective wireless power harvesting and data transmission.
Conclusions:
- The presented integrated device offers a promising solution for wireless neurotransmitter sensing.
- This technology can advance the study of neural pathways and neurological disorders.
- The device's performance metrics support its potential for in vivo applications.
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