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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
[Intelligence and irritable bowel syndrome]
1Académico de Número.
Abstract:
The Syndrome of Irritable Intestine (SII) is a chronic functional dysfunction that it is characterized by abdominal pain and changes of intestinal rhythm without demonstrable organic alteration. It is avery prevelent dysfunction in the developed countries, there being involved in its physiopathology, among other, the psychosocial factors (illness behavior, social situation, stress, vital events, neuroticism, anxiety and somatization). However no study has been carried out on the Rational Intelligence and Experiential Intelligence or Constructive Thought in patient with SII in spite of knowing that the cognitive processes participate in its genesis. On the hypothesis that the patients with SII would have an experiencial intelligence smaller that the fellows controls, 100 cases of SII and 100 controls have been studied, being excluded of both patients groups with intellectual deficit or psychiatric illness in the last year. The cases of SII were distributed in two groups, one of 50 cases that habitually consulted with the doctor and other 50 that didn't make it. All the participants completed specific tests to evaluate all the psychological factors and Rational Intelligence and the Constructive Thought. The results show an alteration of the psychological factors in the SII, expressed by the antecedents of vital events, m even significant of anxiety feature and anxiety and a neuroticism statistically significant. As for Rational Intelligence and Experiential Intelligence in the SII, it was observed that to Rational Intelligence is same in the patients with SII that in the controls. Only in the group of SII that habitually consulted with the doctor a slightly significant decrease of the intellectual coefficient it was observed. As for the Experiential Intelligence a significant decrease of the Constructive Thought was observed in the patients with SII in comparison with the group control. Of their components a decrease of the emotionality exists and of the effectiveness, an increase of the superstitious thought and of the rigidity, being the occult thought and the illusion is the same as in the group control. In synthesis, they are associated factors to suffer SII a bigger neuroticism and an increase of the level of anxiety feature and state, and of the vital stressful events, as well as a decrease of the Constructive Thought. On the contrary they would be associated factors to consult the doctor an increase of the anxiety, a decrease of the Constructive Thought and a decrease of Rational Intelligence. The implications of these discoveries can be physiopathological and therapeutic, since the Experiencial Intelligence is relates with the stress grade auto-generated by the "normal" events of the daily life. Questions without answering are if it could be the biological answer to this auto-generated stress an important factor in the pathogenia of the SII or if this stress could be the nexus of union of the SII with the neuroticism and the anxiety. As for the therapy, and since the Experiential Intelligence is amendable, it would be necessary to think about if the modification of the Experiential Intelligence by means of a therapeutic intervention would bear an improvement of the symptoms of the SII.
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