[IRRITABLE BOWEL SYNDROME. NEW HORIZONS]

Irritable bowel syndrome is a chronic disorder of complex genesis. Infections, indiscriminate use of antibiotics and bowel cleansing may affect the composition of the microbiota. Knowledge of host-microbiota interaction is important to deepen their pathogenesis and allow therapeutic modulation of the microbiota. The interaction between the microbiota, the immune system and the enteric nervous system is not yet well understood, but could be important in the pathophysiology of the disorder. New therapeutic possibilities found with prebiotics, probiotics, new painkillers and antibiotics such as rifaximin. The modification of the fecal microbiota by transplantation may become a future therapeutic option.