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The effect of steric bulk in Sonogashira coupling reactions
Markus an der Heiden1, Herbert Plenio
1Anorganische Chemie im Zintl-Institute, TU Darmstadt, Petersenstr. 18, 64287, Darmstadt, Germany.
Abstract:
The rates of Sonogashira coupling reactions using [Pd-PR(3)] complexes depend on a combination of the steric bulk of phosphines and substrates; however, below a critical cone angle of ca. 170 degrees the catalytic activity drops drastically.
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