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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Radiosurgery for intracranial meningiomas.
John Y K Lee1, Douglas Kondziolka, John C Flickinger
1Department of Neurological Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA.
Progress in Neurological Surgery
|February 24, 2007
Summary
Gamma Knife radiosurgery offers excellent tumor control for intracranial meningiomas, achieving 93% long-term rates for benign types. This minimally invasive treatment provides a safe and effective option for managing these common brain tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Meningiomas are common, often benign, intracranial tumors frequently involving critical neurovascular structures.
- Surgical resection can be challenging due to tumor location, limiting complete removal.
- Gamma Knife radiosurgery presents a minimally invasive therapeutic alternative.
Purpose of the Study:
- To evaluate the efficacy and safety of Gamma Knife radiosurgery for intracranial meningiomas.
- To assess long-term tumor control rates and adverse effects.
- To determine its role as primary or adjuvant therapy.
Main Methods:
- Retrospective review of 964 patients treated with Gamma Knife radiosurgery between 1987 and 2004.
- Focus on skull base meningiomas.
- Analysis of imaging and clinical follow-up data.
Main Results:
- Achieved 93% 5- and 10-year actuarial tumor control for benign meningiomas.
- Reported 5-year control rates of 83% for atypical and 72% for malignant meningiomas.
- Adverse radiation effects ranged from 5.7% to 16%, decreasing with improved imaging and dosimetry.
Conclusions:
- Gamma Knife radiosurgery is a highly effective treatment for intracranial meningiomas.
- It offers durable tumor control as both primary and adjuvant therapy.
- Minimal adverse sequelae are associated with the procedure.
