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Coagulase-negative staphylococcus in chronic prostatitis.
1Department of Urology, Queen's University, Kingston General Hospital, Ontario, Canada.
The Journal of Urology
|February 1, 1992
Summary
Coagulase-negative staphylococci may cause chronic bacterial prostatitis in men. These bacteria were found in prostatic tissue despite antibiotic treatment failure, suggesting a role in persistent infection.
Area of Science:
- Urology
- Microbiology
- Pathology
Background:
- Chronic bacterial prostatitis is a challenging condition.
- Antibiotic resistance is a growing concern in prostatitis treatment.
- Coagulase-negative staphylococci are increasingly recognized as potential pathogens.
Purpose of the Study:
- To investigate the role of coagulase-negative staphylococci in antibiotic-refractory prostatitis.
- To identify the presence and location of bacteria in prostatic tissue after failed antibiotic therapy.
Main Methods:
- Intensive study of three male patients with prostatitis and coagulase-negative staphylococci.
- Repeat cultures of prostatic fluid and prostatic biopsies.
- Histological and ultrastructural examination of prostatic tissue.
Main Results:
- Coagulase-negative staphylococci were cultured from biopsied prostatic tissue.
- Gram-positive staphylococci identified in microcolonies on prostatic ductal walls.
- Bacteria persisted despite previous antibiotic treatment.
Conclusions:
- Coagulase-negative staphylococci may be implicated in the pathogenesis of chronic bacterial prostatitis.
- The findings suggest a potential role for these bacteria in persistent prostatic infections.
- Further research is needed to understand the mechanisms of infection and develop targeted therapies.