Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Needle-based refractive index measurement using low-coherence interferometry.

Adam M Zysk1, Steven G Adie, Julian J Armstrong

  • 1Biophotonics Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Optics Letters
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosing Cerebrospinal Fluid Shunt Failure: Systematic Review and Meta-Analysis of Noninvasive and Minimally Invasive Tests in Children and Adults.

Neurosurgery·2025
Same author

A Multicenter Study of Noninvasive Wireless Assessment of Cerebrospinal Fluid Shunt Function in Hydrocephalus Patients.

Neurosurgery·2025
Same author

The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.

Cancers·2024
Same author

The distribution of breast density in women aged 18 years and older.

Breast cancer research and treatment·2024
Same author

Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA.

Scientific reports·2024
Same author

Quantification of smooth muscle in human airways by polarization-sensitive optical coherence tomography requires correction for perichondrium.

American journal of physiology. Lung cellular and molecular physiology·2024
Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026
Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026
Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026
Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026
Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026
Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026
See all related articles

A new needle device measures tissue refractive index and scattering using low-coherence interferometry. This innovation enables needle-based diagnostics by analyzing optical properties of biological samples.

Area of Science:

  • Biomedical Optics
  • Optical Engineering
  • Materials Science

Background:

  • Accurate measurement of optical properties like refractive index and scattering is crucial for biological and medical diagnostics.
  • Existing methods may lack the precision or accessibility required for in-situ tissue analysis.
  • Low-coherence interferometry offers non-invasive optical characterization capabilities.

Purpose of the Study:

  • To introduce a novel needle-based device for measuring refractive index and scattering.
  • To demonstrate the device's integration with optical coherence tomography (OCT) systems.
  • To validate the device's performance using known tissues and materials in the near-infrared spectrum.

Main Methods:

  • Development of a needle-based probe for low-coherence interferometry.

Related Experiment Videos

  • Integration of the probe into the sample arm of an OCT system.
  • Measurement of optical path length and scattering response within a fixed-width channel.

    • Main Results:

    • Successful near-infrared measurements of refractive index and scattering for various tissues and materials.
    • Demonstration of the device's ability to detect optical property variations.
    • Validation against samples with established optical characteristics.

    Conclusions:

    • The developed needle device effectively measures refractive index and scattering using low-coherence interferometry.
    • The device shows potential for medical and biological diagnostics by leveraging tissue refractive index variations.
    • This technology offers a new approach for in-situ analysis accessible via needle insertion.