Related Experiment Video
Updated: Jul 16, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue
O V Pavlov1, D V Lalayan, S A Sel'kov
1Laboratory of Immunology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.
Abstract:
Secretion of IL-1alpha, IL-1beta, IL-6, IL-10, and TNF-alpha cytokines by villous chorion cultures (7-14 weeks) during normal pregnancy and in spontaneous abortions was studied. Secretion of IL-1alpha and IL-6 increased 4.5 and 7.3 times in miscarriages, while secretion of IL-1beta, IL-10, and TNF-alpha decreased. LPS stimulated the production of IL-1alpha and IL-6 in samples obtained during surgical abortion. LPS stimulated IL-1alpha and TNF-alpha secretion in miscarriages, while the level of IL-6 production decreased significantly. It is hypothesized that increased production of IL-1alpha and IL-6 and attenuation of the antiinflammatory effect of IL-10 play an important role in the pathogenesis of miscarriages at early stages of gestation. The results suggest that cytokine regulation of the fetus rejection is different at early and late stages of gestation.
More Related Videos
Related Concept Videos
Renewal of Intestinal Stem Cells
Overview of Secretory Vesicles
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Hormonal Regulation
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Regulation of Hormone Secretion
Humoral stimuli,...

