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Updated: Jul 16, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
The old is new again: asparagine oxidation in calcium-dependent antibiotic biosynthesis
Andrew S Worthington1, Michael D Burkart
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
Abstract:
Non-ribosomal peptides are built from both proteinogenic and non-proteinogenic amino acids. The latter resemble amino acids but contain modifications not found in proteins. The recent characterization of a non-heme Fe(2+) and alpha-ketoglutarate-dependent oxygenase that stereospecifically generates beta-hydroxyasparagine, an unnatural amino acid building block for the biosynthesis of calcium-dependent antibiotic, a lipopeptide antibiotic. This work improves our understanding of how these non-proteinogenic amino acids are synthesized.
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