Related Experiment Video
Updated: Jul 16, 2026
09:07
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Division of labor: specialization of sphingosine kinases in mast cells
1National Heart, Lung, and Blood Institute, National Institutes of Health, Room 8N109/Bldg. 10, Bethesda, MD 20892, USA. beavenm@nhlbi.nih.gov
Immunity
|March 23, 2007
Abstract:
Generation of sphingosine-1-phosphate by sphingosine kinases (SphKs) promotes allergic inflammatory diseases, but the roles of the individual SphK isoforms are unclear. Olivera et al. (2007) show that SphK2 regulates mast cell activation whereas SphK1 enhances susceptibility to antigen challenge in vivo.
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