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Updated: Jul 15, 2026
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
Effect of mesenchymal stem cell transplantation on cognitive functions in rats with ischemic stroke
I B Sokolova1, O R Fedotova, N N Zin'kova
1Trans-Tekhnologiya Company, Russian Academy of Medical Sciences, St. Petersburg.
Abstract:
The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals.