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Related Experiment Videos

Verifying liquid-handler performance for complex or nonaqueous reagents: a new approach.

Keith J Albert1, John Thomas Bradshaw, Tanya R Knaide

  • 1Artel, Inc., Technical Marketing, 25 Bradley Drive, Westbrook, ME 04092, USA. kalbert@artel-usa.com <kalbert@artel-usa.com>

Clinics in Laboratory Medicine
|April 10, 2007
PubMed
Summary

Automated liquid handlers are crucial for drug discovery. New methods improve the accuracy of dispensing complex or nonaqueous reagents, enhancing high-throughput screening performance.

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Area of Science:

  • Biotechnology
  • Assay Development
  • Drug Discovery

Background:

  • Multichannel volume dispensing devices, like automated liquid handlers, are essential for high-throughput screening (HTS) in drug discovery.
  • Accurate reagent delivery is critical for the reliability and reproducibility of HTS assays.
  • Current methods for assessing performance often struggle with complex or nonaqueous reagents.

Purpose of the Study:

  • To review and discuss recent advancements in methods for assessing the performance of automated liquid handlers.
  • To focus on techniques applicable to dispensing complex or nonaqueous reagents.
  • To highlight the importance of accurate dispensing for broader scientific adoption.

Main Methods:

  • Review of recent research literature on liquid handling performance assessment.

Related Experiment Videos

  • Analysis of methods applicable to diverse reagent types, including nonaqueous solutions.
  • Discussion of challenges and solutions in accurate volume dispensing.

    • Main Results:

    • Recent research expands existing methods for assessing liquid handler performance.
    • New approaches enable more accurate dispensing of complex and nonaqueous reagents.
    • Improved assessment techniques lead to more reliable HTS results.

    Conclusions:

    • Enhanced methods for assessing automated liquid handler performance are crucial for advancing drug discovery.
    • Accurate dispensing of varied reagent types can significantly improve HTS reliability.
    • Wider adoption of these improved protocols promises broad impact across scientific communities.