Related Experiment Video
Updated: Jul 15, 2026
08:45
Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
[Melatonin against surgical stress]
Bülent Kücükakin1, Ismail Gögenur, Jacob Rosenberg
1Gentofte Hospital, Kirurgisk Gastroenterologisk Afdeling D. bulkuc01@gentoftehosp.kbhamt.dk
Ugeskrift for Laeger
|April 18, 2007
Summary
Surgery causes oxidative stress, increasing heart risks. The hormone melatonin, known for antioxidant effects, may protect adult patients post-surgery, warranting further investigation.
Area of Science:
- Biochemistry
- Physiology
- Medical Science
Context:
- Surgery is a significant stressor, inducing oxidative stress.
- Oxidative stress is closely linked to postoperative myocardial ischemia.
- The antioxidant properties of melatonin are well-documented.
Purpose:
- To explore the potential therapeutic role of melatonin in mitigating surgery-induced oxidative stress.
- To investigate the efficacy of melatonin in preventing postoperative myocardial ischemia in adult patients.
Summary:
- Melatonin, an endogenous hormone with proven antioxidant effects in experimental models and neonates, has not been studied in adult surgical patients.
- This study hypothesizes a potential benefit of melatonin in managing acute oxidative stress following surgery.
- Further research is needed to confirm melatonin's protective effects in adult surgical patients.
Impact:
- Highlights a potential novel therapeutic strategy for reducing cardiac complications after surgery.
- Suggests melatonin as a candidate for clinical trials in perioperative care.
- Opens avenues for research into antioxidant interventions for surgical patients.
Related Concept Videos
01:19Management of Insomnia
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
01:23Sedatives and Hypnotics: Overview
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...