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Using criteria to establish nutrient intake values (NIVs).

Allison A Yates¹

¹Beltsville Human Nutrition Research Center, USDA/ARS, 110300 Baltimore Ave., Beltsville, MD 20705, USA. Allison.Yates@ars.usda.gov

Food and Nutrition Bulletin

|May 25, 2007

Summary

Determining the average nutrient requirement (ANR) is complex, as the chosen criterion for nutrient adequacy impacts the ANR value. Understanding nutrient variability is crucial for setting intake levels with defined probabilities of adequacy.

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Area of Science:

Nutritional Science
Human Metabolism
Dietary Reference Intakes

Background:

The average nutrient requirement (ANR) is a key nutrient intake value (NIV) representing adequacy for 50% of a population group.
ANR determination is complex, influenced by the chosen criterion for nutrient adequacy and potential for varied physiological responses.
Existing data often lack dose-response information, complicating the precise identification of the ANR.

Purpose of the Study:

To discuss the complexities in determining the average nutrient requirement (ANR).
To highlight the importance of selecting and justifying criteria for nutrient adequacy.
To explore methods for establishing ANRs using available human nutrient study data and considering variability.

Main Methods:

Review of criteria for defining nutrient adequacy and their impact on ANR values.
Discussion of human nutrient study types and sample size considerations for data collection.
Analysis of nutrient requirement variability and its influence on predicting intake levels for group adequacy.

Main Results:

The ANR is highly dependent on the selected criterion for nutrient adequacy, potentially leading to different requirement values.
Three intake levels (below, at, and above the requirement) are useful for estimating the ANR.
Variability in nutrient requirements is a critical factor in establishing intake levels with defined probabilities of adequacy.

Conclusions:

Clear identification and rationale for chosen adequacy criteria are essential for harmonized NIV development.
Understanding and accounting for nutrient requirement variability are vital for accurate ANR and individual nutrient level (INLx) estimations.
Special considerations are needed for energy requirements, and case examples like vitamin A illustrate the impact of variability.