Necrotizing pancreatitis
Steven J Hughes1, Georgios I Papachristou, Michael P Federle
1Section of Gastrointestinal Surgery, Department of Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. hughess2@upmc.edu
Abstract:
Necrotizing pancreatitis continues to challenge clinicians, and few other medical subjects currently elicit as much debate. Host characteristics or underlying differences in pathophysiology that lead to pancreatic necrosis remain poorly understood. Severe pancreatitis follows a two-phase clinical course. The early first phase manifests the features of the systemic inflammatory response syndrome, and the second late phase is characterized by infectious complications. This article presents a multidisciplinary literature-based approach to the treatment of patients with necrotizing pancreatitis.
Related Concept Videos
Acute Pancreatitis II: Pathophysiology
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

