Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlation between drug dissolution and polymer hydration: a study using texture analysis.

Hongtao Li1, Xiaochen Gu

  • 1Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2.

International Journal of Pharmaceutics
|June 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated volatile and non-volatile metabolomics reveal aroma chemotypes in Capsicum cultivars.

Food chemistry: X·2026
Same author

Development of potent BChE/Nrf2 modulators for Alzheimer's disease treatment via dual suppression of ferroptosis.

European journal of medicinal chemistry·2026
Same author

Repeatability and agreement of planar lumbar range of motion measured by dynamic fluoroscopy and optical motion capture in an ovine cadaveric model.

Frontiers in bioengineering and biotechnology·2026
Same author

[Clinical characteristics of Lingnan acupuncture for depression based on the theory of "treating and regulating the mind"].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2026
Same author

A three-pronged strategy with minimalist nattokinase nanocomposite eye drops breaks the vicious cycle in ultraviolet-B-induced cataract.

Journal of nanobiotechnology·2026
Same author

Anti-adenylate kinase 5 encephalitis: Case series and review of <sup>18</sup>F-DPA714 PET/MRI radiographic changes.

Journal of neuroimmunology·2026
Same journal

Design and evaluation of a pump-free ultrasonic atomization-driven hollow microneedle array for transdermal drug delivery.

International journal of pharmaceutics·2026
Same journal

Predicting milling performance of pharmaceutical crystals from elastic modulus.

International journal of pharmaceutics·2026
Same journal

Lipid digestion- driven drug fate as a key determinant of SNEDDS performance: Mechanistic basis of absorption and in vitro- in vivo disconnect.

International journal of pharmaceutics·2026
Same journal

Redox-responsive nanomedicine beyond glutathione: harnessing reactive oxygen species and emerging endogenous triggers for precision drug delivery.

International journal of pharmaceutics·2026
Same journal

Preventing tablet defects through vacuum-assisted deaeration of a powder bed.

International journal of pharmaceutics·2026
Same journal

Approaches for enhancing bioavailability of macromolecular drugs.

International journal of pharmaceutics·2026
See all related articles

Texture analysis offers a novel method for characterizing modified-release tablets. This study links drug dissolution and polymer hydration in pseudoephedrine hydrochloride matrix tablets using a texture analyzer.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Modified-release drug delivery systems are crucial for optimizing therapeutic outcomes.
  • Understanding polymer hydration and its effect on drug release is essential for formulation design.

Purpose of the Study:

  • To evaluate the correlation between drug dissolution and polymer hydration in pseudoephedrine hydrochloride modified-release matrix tablets.
  • To explore the application of texture analysis in characterizing these drug delivery systems.

Main Methods:

  • Matrix tablets of pseudoephedrine hydrochloride were formulated using Polyox WSR301 (PEO) and Compritol 888ATO (GB).
  • Drug dissolution was assessed using USP Method II.
  • Polymer swelling and hydrogel properties were measured using a texture analyzer.

Related Experiment Videos

Main Results:

  • Increased PEO and GB content reduced initial drug dissolution but did not affect overall release within 6 hours.
  • Linear correlations were found between drug dissolution, polymer content, and texture analysis parameters (hydrogel thickness, AUC(TA)).
  • Texture analysis effectively characterized the modified-release matrix tablets.

Conclusions:

  • Texture analysis provides valuable insights into the behavior of modified-release matrix tablets.
  • The study demonstrates a novel application of texture analyzers in pharmaceutical research and development for drug release characterization.