Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C1: molecular interactions with activating systems.

R B Sim1, K B Reid

  • 1Dept of Biochemistry, University of Oxford, UK.

Immunology Today
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C2 by-pass: Cross-talk between the complement classical and alternative pathways.

Immunobiology·2022
Same author

Complement research in the 18th-21st centuries: Progress comes with new technology.

Immunobiology·2016
Same author

Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins.

Immunology today·2014
Same author

[Circulating immune complexes in families with positive history of ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2008
Same author

Resistance of the Echinococcus granulosus cyst wall to complement activation: analysis of the role of InsP6 deposits.

Parasite immunology·2008
Same author

Collectins and host defence.

Novartis Foundation symposium·2007
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

This review details the molecular interactions of C1q with ligands, crucial for initiating the classical complement pathway cascade. Understanding these early events is key to deciphering immune system regulation.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Complement activation is a critical immune process.
  • The classical pathway is initiated by C1q binding to ligands.
  • Decades of research have improved understanding of complement proteins.

Purpose of the Study:

  • To review the molecular interactions between C1q and its ligands.
  • To elucidate the initiation of the classical complement pathway cascade.
  • To provide an updated perspective on complement system research.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of protein interactions and molecular events.
  • Synthesis of current knowledge on C1q and its ligands.

Related Experiment Videos

Main Results:

  • Detailed examination of C1q-ligand binding dynamics.
  • Identification of key molecular events in classical pathway initiation.
  • Highlighting the significance of C1q in immune response.

Conclusions:

  • C1q-ligand interactions are central to initiating the classical complement cascade.
  • Continued research is vital for understanding immune regulation and developing therapeutics.
  • This review consolidates current knowledge on early complement activation events.