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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Molecularly templated materials in chemical sensing.
Ellen L Holthoff1, Frank V Bright
1Department of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, USA.
Analytica Chimica Acta
|June 26, 2007
Summary
Researchers are developing molecularly templated polymers as durable, affordable alternatives to biological sensors. These novel materials mimic biorecognition elements for improved biosensing applications, offering reusable and stable recognition capabilities.
Area of Science:
- Materials Science
- Analytical Chemistry
- Biotechnology
Background:
- Biologically-based recognition elements (e.g., antibodies, aptamers) are crucial for biosensors but are often expensive and unstable.
- There is a need for cost-effective, robust, and reusable alternatives to traditional biorecognition elements.
Purpose of the Study:
- This review summarizes research on molecularly templated polymers as replacements for biorecognition elements.
- It explores the development of organic and inorganic polymers with analyte binding capabilities similar to biomolecules.
Main Methods:
- The review discusses molecular templating in organic and inorganic (xerogel) polymers to create synthetic recognition materials.
- It highlights recent advancements in integrating analyte recognition and transduction directly within these templated polymers.
Main Results:
- Molecularly templated polymers demonstrate potential as synthetic biorecognition elements.
- Simultaneous incorporation of analyte recognition and transduction in templated materials is a key development.
Conclusions:
- Molecularly templated polymers offer a promising avenue for developing inexpensive, robust, and reusable biosensing materials.
- Further research is needed to address remaining challenges and optimize these synthetic recognition systems.
