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Effect of suction ring application during LASIK on goblet cell density.
Jose Luis Rodriguez-Prats1, Islam M Hamdi, Alejandra E Rodriguez
1VISSUM Instituto Oftalmológico de Alicante, Spain.
Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|June 30, 2007
Summary
LASIK surgery significantly reduces conjunctival goblet cells, a key factor in post-LASIK dry eye. Cell counts remain low one month after the procedure, indicating lasting effects on ocular surface health.
Area of Science:
- Ophthalmology
- Ocular Surface Disease
- Corneal Surgery
Background:
- Dry eye is a common complication following LASIK surgery.
- Conjunctival goblet cells play a crucial role in maintaining ocular surface hydration and health.
Purpose of the Study:
- To investigate the impact of LASIK surgery on conjunctival goblet cells.
- To explore the role of goblet cell changes in the development of post-LASIK dry eye.
Main Methods:
- Prospective study involving 22 eyes undergoing LASIK for myopia correction.
- Conjunctival impression cytology samples collected preoperatively, at 1 week, and 1 month postoperatively.
- Goblet cell density quantified using standardized cytological techniques.
Main Results:
- A statistically significant decrease in goblet cell density was observed at 1 week and 1 month post-LASIK.
- Goblet cell counts were significantly reduced compared to preoperative levels.
- The reduction in goblet cells persisted at 1 month, suggesting a lasting effect.
Conclusions:
- The microkeratome suction ring used in LASIK induces changes in the perilimbic conjunctiva.
- These conjunctival alterations, particularly the loss of goblet cells, contribute to dry eye syndrome post-LASIK.
- Goblet cell density remains compromised at least one month after surgery.
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