Related Experiment Video
Updated: Jul 13, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
The paradox of dysfunctional high-density lipoprotein
Benjamin J Ansell1, Gregg C Fonarow, Alan M Fogelman
1Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. bansell@mednet.ucla.edu
Current Opinion in Lipidology
|July 11, 2007
Summary
High-density lipoprotein (HDL) can become proinflammatory during atherosclerosis or inflammation. Treatments and resolving inflammation can restore HDL's protective functions, reducing cardiovascular risk.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Immunology
Background:
- High-density lipoprotein (HDL) typically possesses atheroprotective properties.
- Systemic inflammation and atherosclerosis can alter HDL functionality.
Purpose of the Study:
- To review how HDL loses its protective characteristics and becomes proinflammatory.
- To discuss factors influencing HDL's dual role in inflammation.
Main Methods:
- Review of current scientific literature.
- Analysis of chemical and structural changes in HDL particles.
- Evaluation of therapeutic interventions impacting HDL function.
Main Results:
- Altered HDL impedes reverse cholesterol transport and promotes LDL oxidation and vascular inflammation.
- HDL's inflammatory potential depends on its molecular composition.
- Statins and lifestyle changes can improve proinflammatory HDL characteristics.
Conclusions:
- HDL can become dysfunctional and proinflammatory under certain conditions.
- Systemic inflammation resolution or specific treatments can reverse HDL dysfunction.
- Targeting HDL function offers novel cardiovascular risk reduction strategies.
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