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X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir
Amit Das1, Dharmaraj Ramachandra Rao, Madhusoodan Vijayacharya Hosur
1Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India.
Abstract:
We report here the 2.5A structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.
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