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Updated: Jul 13, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Interactions between hyperthermia and cytotoxic drugs
1Charité-Centrum Tumormedizin, Charité Universitätsmedizin Berlin, Germany. hyperthermia@charite.de
Abstract:
Pioneering studies of the 1970s and 1980s demonstrated that heat application induces cell death at temperatures of more than 43 degrees C in cell cultures and animal experiments, and sensitises tumour cells to radiation and certain cytotoxic drugs in the temperature range of 39 degrees C - 43 degrees C. Further research revealed further details of the complex interactions of heat and drugs in the living organism. In this chapter, we discuss the fundamentals of heat-drug interactions, their variations between certain classes of cytotoxic agents, induction and reversal of drug resistance under hyperthermic conditions, and pharmacological aspects of drug administration during hyperthermia.
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