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Updated: Jun 25, 2026

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 27, 2013
Immunopathogenesis of psoriasis.
1Department of Dermatology, Hinduja Hospital, Mumbai.
Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
Summary
Psoriasis treatment involves targeting T lymphocyte activation and blocking inflammatory cytokines using biologicals. These therapies aim to manage the immune response underlying this chronic skin condition.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Psoriasis is an immune-mediated skin disease.
- It is characterized by T lymphocyte activation and a Th1 immune response.
- Inflammatory cytokines play a key role in psoriasis pathogenesis.
Purpose of the Study:
- To review the mechanisms of T cell activation in psoriasis.
- To discuss the role of biologicals in targeting these mechanisms.
- To explore the therapeutic strategies for psoriasis using biological agents.
Main Methods:
- Review of immunological pathways in psoriasis.
- Analysis of T cell activation mechanisms.
- Examination of cytokine signaling in disease development.
- Evaluation of biological therapies targeting immune pathways.
Main Results:
- Psoriasis pathogenesis involves aberrant T lymphocyte activation.
- Th1 immune responses and associated cytokines drive disease progression.
- Biological therapies effectively target key immune mediators in psoriasis.
Conclusions:
- Targeting T cell activation and proinflammatory cytokines is a key therapeutic strategy for psoriasis.
- Biologicals offer effective treatment options by modulating the immune response.
- Further research into immunological mechanisms can lead to novel psoriasis treatments.
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