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Updated: Jul 13, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Vein of galen aneurysmal malformations
H Alvarez1, R Garcia Monaco, G Rodesch
1Service de Neuroradiologie Diagnostique et Thérapeutique, Hôpital Bicêtre 78, rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, Paris, France.
Abstract:
Different types of malformations share a dilated vein of Galen, but only one of them is a true vein of Galen aneurysmal malformation (VGAM). The optimal window of opportunity for treatment is between 4 and 5 years of months [corrected], because this allows the child to grow and mature. Heart failure and hydrocephalus respond favorably to embolization. Cerebrospinal fluid ventricular shunting, if needed, should be performed after the embolization. The transvenous approach carries significantly elevated morbidity and mortality and is rarely indicated. Anatomic cure of the VGAM is not the main goal of treatment; the ultimate goal is control of the malformation to allow the brain to mature and develop normally.
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