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Perfusion mapping with multiecho multishot parallel imaging EPI.

Rexford D Newbould1, Stefan T Skare1, Thies H Jochimsen2

  • 1Lucas MRS/I Center, Department of Radiology, Stanford University, Stanford, California, USA.

Magnetic Resonance in Medicine
|July 31, 2007
PubMed
Summary
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This study introduces a new pseudo-single-shot EPI method for dynamic susceptibility-contrast perfusion MRI. It enhances image quality and quantitative accuracy by reducing signal saturation and geometric distortions.

Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Neuroimaging

Background:

  • Echo-planar imaging (EPI) is standard for DSC perfusion MRI but has geometric distortions and signal saturation issues.
  • Long echo times (TEs) in DSC-EPI cause arterial input signal saturation, leading to hemodynamic quantitation errors.
  • Susceptibility-induced distortions and T(1) shortening effects further complicate accurate perfusion measurements.

Purpose of the Study:

  • To develop a rapid volumetric EPI technique addressing geometric distortions and signal saturation in DSC perfusion MRI.
  • To improve the quantitative accuracy of hemodynamic parameters derived from perfusion MRI.
  • To enhance image quality and signal-to-noise ratio (SNR) in perfusion imaging.

Main Methods:

  • Utilized interleaved shot acquisition and parallel imaging (PI) for rapid volumetric pseudo-single-shot (ss)EPI.

Related Experiment Videos

  • Employed multiecho readouts to enable unbiased R(*)(2) mapping and mitigate signal saturation.
  • Reduced readout lengths to allow multiple echo acquisitions with high temporal resolution and spatial coverage.

    • Main Results:

    • The ssEPI method achieved effective T(*)(2) blur and susceptibility distortions comparable to multishot EPI.
    • Multiecho acquisition enabled unbiased R(*)(2) mapping, correcting for signal saturation and T(1) shortening.
    • The technique mitigated SNR reduction from PI and improved overall image quality in volunteers and stroke patients.

    Conclusions:

    • The developed ssEPI acquisition scheme significantly improves quantitative accuracy in DSC perfusion MRI.
    • This method effectively addresses signal saturation and T(1) contamination, crucial for reliable hemodynamic assessment.
    • The technique represents a significant advancement for rapid time-series acquisitions and quantitative MR PWI.